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Jessica M. Hauth
Ms. Hauth is an associate in the Biotechnology & Life Sciences Group at Malloy & Malloy, P.A., where she focuses her practice in patent preparation, prosecution, analyses, and disputes. Her technical experience includes developmental biology, genetics, cell biology, molecular biology, heterochromatin assembly and maintenance, and RNAi use and characterization.
Ms. Hauth conducted undergraduate research at Emory University involving the genetic and phenotypic characterization of NADPH oxidase (Nox) genes through the development and implementation of double stranded RNAi constructs in D. melanogaster, utilizing techniques including molecular biology of cloning and expression vectors, DNA gel electrophoresis, embryo injection of knock-out vectors, and phenotypic characterization of resulting mutants. She also conducted additional undergraduate research at the Georgia Institute of Technology in the field of organic chemistry, specifically in the synthesis of a bis(diphenylphosphino)-1,1’-binaphthyl (BINAP) dendrimer-supported catalyst for use in the hydrogenation of ketones in supercritical carbon dioxide (scCO2), for applications in pharmaceutical drug production. She implemented analytical chemistry techniques for analyzing the resulting synthesis products, including thin layer chromatography (TLC), gravity filtration on silica gel column, and nuclear magnetic resonance (NMR) spectroscopy.
Ms. Hauth’s graduate research at Emory University in the Biochemistry, Cell and Developmental Biology program was focused on the mechanisms of heterochromatin regulation in the germ line of C. elegans, and the role of RNAi as a possible mechanism. Her research utilized mutant strains of C. elegans lacking various RNAi genes, assaying for enrichment of histone H3 lysine 9 dimethylation (H3K9me2) on unpaired chromosomes, such as the X chromosomes in males and extrachromosomal transgenic arrays, in germ cells. She utilized the techniques of genetic crossing, immunofluorescence, differential interference (DIC) microscopy, and phenotypic characterization of the mutants. She also performed research involving the role of insulin signaling in muscle wasting from renal failure and diabetes utilizing cultured muscle cells, and studied galactosemia using the yeast S. cerevisiae. In addition to research, her graduate work also included coursework in biochemistry, cell biology, genetics, laboratory techniques, and grant writing.
Technical Publications
Maine, E.M., Hauth, J., Ratliff, T., Vought, V.E., She, X., and Kelly, W.G., “EGO-1, a Putative RNA-Dependent RNA Polymerase, Is Required for Heterochromatin Assembly on Unpaired DNA during C. elegans Meiosis,” Current Biology 15, 1972-1978 (2005).
Hauth, J., “Connecting RNA interference and heterochromatin in the germline of Caenorhabditis elegans,” Master’s Thesis, Emory University (2005).
Contact: jhauth@malloylaw.com
