Gene A. Lang, Ph.D.

 

  

Dr. Lang is an associate in the Biotech/Life Sciences Group at Malloy  & Malloy, P.A. He assists in the preparation and prosecution of U.S.  patent applications. His technical experience includes cellular and  molecular biology, embryonic stem (ES) cell manipulation, genetically  engineered mice, recombinant DNA techniques, gene expression profiling,  and embryology.


Dr. Lang's undergraduate research involved cell cycle analysis using the Aspergillus nidulans model system. He was awarded the Sigma Xi Undergraduate Student Research grant and the Beta Beta Beta Research Scholarship Foundation grant.

Dr. Lang's graduate research was focused in the area of cancer genetics, specifically in the generation and characterization of mouse models of human cancer. While in graduate school, he was awarded the Molecular Genetics of Cancer pre-doctoral training grant from the National Institutes of Health (NIH).

Following his graduate studies, Dr. Lang was awarded the Doris Rapee Endowed Scholarship by Franklin Pierce Law Center. The scholarship recognizes creativity and innovation in technology.


Technical Publications
Terzian, T., Suh, Y.A., Iwakuma, T., Post, S.M., Neumann, M., Lang, G.A., Van Pelt, C.S., Lozano, G. "The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss," Genes & Development 22, 1337-1344 (2008).

Caulin, C.; Nguyen, T.; Lang, G.A.; Goepfert, T.M.; Brinkley, B.R.; Cai, W.W.; Lozano, G.; Roop, D.R. "An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations," Journal of Clinical Investigation 117, 1893-1901 (2007).

Lang, G. A.; Iwakuma, T.; Suh, Y. A.; Liu, G.; Rao, V. A.; Parant, J. M.; Valentin-Vega, Y.A.; Terzian, T.; Caldwell, L. C.; Strong, L. C.; El-Naggar, A. K.; Lozano, G. "Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome," Cell 119, 861-872 (2004).

Liu, G.; Parant, J. M.; Lang, G.; Chau, P.; El-Naggar, A. K.; Multani, A; Chang, S.; Lozano, G. "Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice," Nature Genetics 36, 63-68 (2004).

McGuire, S. L.; Roe, D. L.; Carter, B. W.; Carter, R. L.; Grace, S. P.; Hays, P. L.; Lang, G. A.; Mamaril, J. L.; McElvaine, A. T.; Payne, A. M.; Schrader, M. D.; Wahrle, S. E.; Young, C. D. "Extragenic suppressors of the nimX2(cdc2) mutation of Aspergillus nidulans affect nuclear division, septation and conidiation," Genetics 156, 1573-84 (2000).

Contact: glang@malloylaw.com

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